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HER3/ErbB3 Antibody Phospho (pY1289)

Rabbit Monoclonal Antibody

  • WB - HER3/ErbB3 Antibody Phospho (pY1289) AJ1341b
    A. Western blot analysis on SKBR3 cell lysate using anti-Phospho-HER3/ErbB3 (pY1289) RabMAb (Cat. #AJ1341b), 1:5000 dilution. Cells were either (A) untreated (B) treated with Neuregulin
  • IF - HER3/ErbB3 Antibody Phospho (pY1289) AJ1341b
    B. Immunofluorescent staining of MCF7 cells using phospho-specific anti-HER3/ErbB3 (pY1289) RabMAb (Cat. #AJ1341b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21860
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2325
Calculated MW 148098 Da
Gene ID 2065
Other Names Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Target/Specificity A phospho-specific peptide corresponding to residues surrounding Tyrosine 1289 of human HER3/ErbB3 was used as an immunogen. The antibody only detects HER3/ErbB3 phosphorylated on Tyrosine 1289.
Dilution WB~~1:5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHER3/ErbB3 Antibody Phospho (pY1289) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERBB3
Synonyms HER3
Function Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Epithelial tissues and brain.
Research Areas
Citations (0)

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HER3/ErbB3 is a member of the ErbB/EGF receptor protein tyrosine kinase family (1,2). Tyrosine phosphorylation of HER3/ErbB3 depends on its association with other ErbB tyrosine kinases (3). Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. HER3/ErbB3 is highly expressed in many cancer cells (4), and it may work together with other Erb members in tumorigenesis and proliferation (5). HER/ErbB3 is phosphorylated by EGFR or ErbB2 through dimeric interactions with HER/ErbB3, on Tyrosine 1289, a docking site for phosphatidylinositol 3-kinase (6).


1. Katoh, M., et al. Biochem Biophys Res Commun. 192: 1189
2. Kraus, M.H., et al. Proc Natl Acad Sci U S A. 86: 9193
3. Guy, P.M., et al. Proc. Natl. Acad. Sci. USA 91: 8132
4. Sithanandam, G., et al. Carcinogenesis 24: 1581
5. Alimandi, M., et al. Oncogene 10: 1813
6. Jie Zhang, The American Journal of Pathology 170(1), 2007

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Cat# AJ1341b
(40 western blots)
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