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HER3/ErbB3 Antibody Phospho (pY1289)

Rabbit Monoclonal Antibody

  • WB - HER3/ErbB3 Antibody Phospho (pY1289) AJ1341b
    A. Western blot analysis on SKBR3 cell lysate using anti-Phospho-HER3/ErbB3 (pY1289) RabMAb (Cat. #AJ1341b), 1:5000 dilution. Cells were either (A) untreated (B) treated with Neuregulin
  • IF - HER3/ErbB3 Antibody Phospho (pY1289) AJ1341b
    B. Immunofluorescent staining of MCF7 cells using phospho-specific anti-HER3/ErbB3 (pY1289) RabMAb (Cat. #AJ1341b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21860
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2325
Calculated MW 148098 Da
Gene ID 2065
Other Names Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Target/Specificity A phospho-specific peptide corresponding to residues surrounding Tyrosine 1289 of human HER3/ErbB3 was used as an immunogen. The antibody only detects HER3/ErbB3 phosphorylated on Tyrosine 1289.
Dilution WB~~1:5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHER3/ErbB3 Antibody Phospho (pY1289) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERBB3
Synonyms HER3
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Epithelial tissues and brain.
Research Areas
Citations (0)

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HER3/ErbB3 is a member of the ErbB/EGF receptor protein tyrosine kinase family (1,2). Tyrosine phosphorylation of HER3/ErbB3 depends on its association with other ErbB tyrosine kinases (3). Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. HER3/ErbB3 is highly expressed in many cancer cells (4), and it may work together with other Erb members in tumorigenesis and proliferation (5). HER/ErbB3 is phosphorylated by EGFR or ErbB2 through dimeric interactions with HER/ErbB3, on Tyrosine 1289, a docking site for phosphatidylinositol 3-kinase (6).


1. Katoh, M., et al. Biochem Biophys Res Commun. 192: 1189
2. Kraus, M.H., et al. Proc Natl Acad Sci U S A. 86: 9193
3. Guy, P.M., et al. Proc. Natl. Acad. Sci. USA 91: 8132
4. Sithanandam, G., et al. Carcinogenesis 24: 1581
5. Alimandi, M., et al. Oncogene 10: 1813
6. Jie Zhang, The American Journal of Pathology 170(1), 2007

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Cat# AJ1341b
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