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Hex Antibody

Rabbit Monoclonal Antibody

  • WB - Hex Antibody AJ1343a
    A. Western blot analysis on (A) MCF-7 and (B) A549 cell lysates using anti-Hex RabMAb (Cat. #AJ1343a), dilution 1:2000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q03014
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3361
Calculated MW 30022 Da
Gene ID 3087
Other Names Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, HHEX, HEX, PRH, PRHX
Target/Specificity A synthetic peptide corresponding to residues in human Hex was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHex Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HEX, PRH, PRHX
Function Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).
Cellular Location Nucleus.
Tissue Location Liver and promyelocytic leukemia cell line HL- 60.
Research Areas
Citations (0)

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Hex, the hematopoietically-expressed homeobox protein (proline-rich homeodomain protein/PRH) is a transcription factor that is important in the control of cell proliferation and differentiation and in the regulation of multiple processes in embryonic development. Hex contains two domains that can independently bring about transcriptional repression. The Hex homeodomain represses transcription by binding to TATA box sequences, whereas the proline-rich N-terminal domain of Hex can repress transcription when attached to a heterologous DNA-binding domain (1). Hex is expressed in primitive endoderm, in some endoderm-derived tissues and in endothelial and hematopoietic precursors. Expression is extinguished during terminal differentiation of endothelial and hematopoietic cells as well as in adult lung (2).


1. Swingler TE, et al. J Biol Chem. 279(33):34938-47, 2004
2. Pellizzari L, et al. Nucleic Acids Res. 28(13):2503-11, 2000

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Cat# AJ1343a
(40 western blots)
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