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Histon H2B Antibody Type 1B

Rabbit Monoclonal Antibody

  • WB - Histon H2B Antibody Type 1B AJ1346a
    A.Western blot analysis on Jurkat cell lysate using anti-Histone H2B Type 1B RabMAb (Cat. #AJ1346a), dilution 1:1000.
  • IHC - Histon H2B Antibody Type 1B AJ1346a
    B. Immunohistochemical analysis of paraffin-embedded human transitional cell carcinoma of urinary bladder using anti-Histone H2B RabMAb (Cat. #AJ1346a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5QNW6
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP2327
Calculated MW 13920 Da
Gene ID 440689
Other Names Histone H2B type 2-F, HIST2H2BF
Target/Specificity A synthetic peptide corresponding to residues on the N-terminus of human Histone H2B Type 1B was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHiston H2B Antibody Type 1B is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.
Citations (0)

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Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). Acetylation of core histones regulates gene expression (2). Histone H2B is primarily acetylated at lysines 5, 12, 15, and 20 (3). Ubiquitylation of Histone H2B at lysine 123 by Rad6 has been implicated in transcriptional activation and lysine methylation on histone H3 (4).


1. Braunstein M, et al. Mol. Cell. Biol. 16:4349
2. Workman JL, Kingston RE,. Annu. Rev. Biochem. 67: 545
3. Cheung, P. et al. Cell103, 263
4. Xiao T, et al. Mol Cell Bio 25:637-651, 2005

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Cat# AJ1346a
(40 western blots)
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