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Histone Deacetylase 2 Antibody (C-term)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1347a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Histone Deacetylase 2 Antibody (C-term) - Product info | |
| Application | WB, IHC, IF
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| Primary Accession | Q92769 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | Y461 |
| Calculated MW | 55364 Da |
| Gene ID 3066 | |
| Other Names HDAC2, Histone deacetylase 2 | |
| Target/Specificity A synthetic peptide corresponding to residues in the C-term of human Histone Deacetylase 2 was used as immunogen. | |
| Dilution WB~~1:1000~5000 IHC~~1:250~500 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Histone Deacetylase 2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Histone Deacetylase 2 Antibody (C-term) - Protein Information | |
| Name HDAC2 | |
| Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development | |
| Cellular Location Nucleus. | |
| Tissue Location Widely expressed; lower levels in brain and lung | |
Histone Deacetylase 2 Antibody (C-term) - Related products
AP1102b: HDAC2 Antibody (C-term)
AP9762c: HDAC2 Antibody (Center)
RI12420: HDAC2 predesign siRNA
BP1102b: HDAC2 Antibody (C-term) Blocking Peptide
BP9762c: HDAC2 Antibody (Center) Blocking Peptide
AJ1347a: Histone Deacetylase 2 Antibody (C-term)
Histone Deacetylase 2 Antibody (C-term) - Application data
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A. Western blot analysis on K562 cell lysate using anti-Histone Deacetylase 2 (C-term) RabMAb (Cat. #AJ1347a), 1:2,000
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B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-Histone Deacetylase 2 (C-term) RabMAb (Cat. #AJ1347a).
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C. Immunofluorescent analysis of HeLa cells using anti-Histone Deacetylase 2 (C-term) RabMAb (Cat. #AJ1347a).
Histone Deacetylase 2 Antibody (C-term) - Research Areas
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BACKGROUND
Histone deacetylase 2 (HDAC2) belongs to the histone deacetylase family type 1 which is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (1). HDAC2 represses transcription and binds transcription factor YY1 to form a large complex (2). It also forms transcriptional repressor complexes by associating with MAD, SIN3, N-CoR and DNMT1 (3-4). Similar to HDAC1 and HDAC3, HDAC2 does not possess a repression domain, but preferentially associates with HDAC1. HDAC2 with HDAC1 is also implicated in a complex of multiproteins that functions through modifying chromatin structure to keep genes silent (5).
REFERENCES
1. Yang, W.-M.; Inouye, C.; Zeng, Y.; Bearss, D.; Seto, E.: Proc. Nat. Acad. Sci. 93: 12845-12850, 1996.
2. Inouye, C. J.; Seto, E.: J. Biol. Chem. 269: 6506-6510, 1994.
3. Tong, J. K., Hassig, C. A., Schnitzler, G. R., Kingston, R. E. & Schreiber, S. L. (1998) Nature (London) 395, 917-921
4. Rountree, M. R.; Bachman, K. E.; Baylin, S. B.: Nature Genet. 25: 269-277, 2000.
5. Hakimi et al. J. Biol. Chem. 278: 7234-7239, 2003
