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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Histone Deacetylase 3 Antibody (C-term)   

Histone Deacetylase 3 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Histone Deacetylase 3 Antibody (C-term) AJ1348a
    A. Western blot analysis on K562 cell lysate using anti-Histone Deacetylase 3 (C-term) RabMAb (Cat. #AJ1348a), 1:10,000
  • IHC - Histone Deacetylase 3 Antibody (C-term) AJ1348a
    B. Immunohistochemical analysis of paraffin-embedded human ovary carcinoma using anti-Histone deacetylase 3 (C-term) RabMAb (Cat. #AJ1348a).
  • IF - Histone Deacetylase 3 Antibody (C-term) AJ1348a
    C. Immunofluorescent staining of HeLa cells using anti-Histone deacetylase 3 (C-term) RabMAb (Cat. #AJ1348a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15379
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y415
Calculated MW 48848 Da
Gene ID 8841
Other Names Histone deacetylase 3, HD3, RPD3-2, SMAP45, HDAC3
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human Histone deacetylase 3 was used as immunogen. This antibody may detect splice isoform 2 (RPD3-2A).
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHistone Deacetylase 3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC3
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Cellular Location Nucleus. Cytoplasm. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803).
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Histone deacetylase 3 belongs to the histone deacetylase family type 1 which actively deacetylate Histones. Currently 3 known isoforms exists (HDAC3, HDAC3A and HDAC3C) (1). HDAC3 represses transcription and binds transcription factor YY1 to form a large complex. N-Cor binds HDAC3 in a different manner than other HDACs. In addition to N-Cor, HDAC3 will form a complex with corepressor SMRT (2). HDAC3 is also known to interact with DAXX, HDAC10 and DACH1.


1. Wen-Ming Yang , Ya-Li Yao , Jian-Min Sun, James R. Davie and Edward Seto. Volume 272, Number 44, Issue of October 31, 1997 pp. 28001-28007
2. Li, J., Wang, J., Nawaz, Z., Liu, J.M., Qin, J. and Wong, J., 2000. EMBO J. 19, pp. 4342

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Cat# AJ1348a
(40 western blots)
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