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>   home   >   Products   >   Primary Antibodies   >   Histone-H2A Antibody Acetyl (K5)   

Histone-H2A Antibody Acetyl (K5)

Rabbit Monoclonal Antibody

  • WB - Histone-H2A Antibody Acetyl (K5) AJ1355a
    A. Western blot analysis on A.) C6 cell lysate and B.) C6+ TSA membrane using anti-Histone H2A, Acetyl-K5 RabMAb (Cat. #AJ1355a), dilution 1:100,000.
  • IHC - Histone-H2A Antibody Acetyl (K5) AJ1355a
    B. Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-Histone H2A, Acetyl-K5 RabMAb (Cat. #AJ1355a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96QV6
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP856Y
Calculated MW 14234 Da
Gene ID 221613
Other Names Histone H2A type 1-A, Histone H2A/r, HIST1H2AA, H2AFR
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Histone H2A was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHistone-H2A Antibody Acetyl (K5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms H2AFR
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.
Citations (0)

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Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). It has been shown that DNA damage induces monoubiquitylation of histone H2A in the vicinity of DNA lesions. Ultraviolet -induced monoubiquitylation of H2A is dependent on functional nucleotide excision repair. It occurs after incision of the damaged strand and forms part of the cellular response to UV damage and suggests a role of this modification in DNA repair-induced chromatin remodeling (3).


1. Braunstein M, et al. Mol. Cell. Biol. 16:4349
2. Workman JL, Kingston RE,. Annu. Rev. Biochem. 67: 545
3. Bergink S, et al. Genes Dev. 20(10):1343-52, 2006.

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Cat# AJ1355a
(40 western blots)
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