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>   home   >   Products   >   Primary Antibodies   >   Histone-H4 Antibody Acetyl (K8)   

Histone-H4 Antibody Acetyl (K8)

Rabbit Monoclonal Antibody

  • WB - Histone-H4 Antibody Acetyl (K8) AJ1360b
    A. Western blot analysis on A.) C6 cell lysate and B.) C6 cell + TSA lysate using anti-Histone H4, Acetyl-K8 RabMAb (Cat. #AJ1360b), dilution 1:10,000.
  • IF - Histone-H4 Antibody Acetyl (K8) AJ1360b
    B. Immunofluorescent staining of Hela cells using anti-Histone H4 RabMAb. (Cat. #AJ1360b).
  • IHC - Histone-H4 Antibody Acetyl (K8) AJ1360b
    C. Immunohistochemical staining of paraffin-embedded human cervical carcinoma using anti-Histone H4 RabMAb (Cat. #AJ1360b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62805
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP1002Y
Calculated MW 11367 Da
Gene ID 121504;554313;8294;8359;8360;8361;8362;8363;8364;8365;8366;8367;8368;8370
Other Names Histone H4, HIST1H4A, H4/A, H4FA
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Histone H4 was used as an immunogen.
Dilution WB~~1:10000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHistone-H4 Antibody Acetyl (K8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms H4/A, H4FA
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.
Citations (0)

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Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). Acetylation of histone H4 thus appears to play a primary role in the structural changes that mediate enhanced binding of transcription factors to their recognition sites within nucleosomes (3). Histone H4 can be reversibly acetylated at lysine residues 5, 8, 12 and 16. It has been shown that, in H4 from human cells, the four lysine residues are acetylated in a preferred, but not exclusive order, namely lysine 16, followed by 12 and 8, followed by 5 (4).


1. Braunstein M, et al. Mol. Cell. Biol. 16:4349
2. Workman JL, et al, Annu. Rev. Biochem. 67: 545
3. Vettese-Dadey M., et al. EMBO J 15(10):2508-18, 1996
4. Turner BM, et al. FEBS Lett 253(1-2):141-5, 1989

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Cat# AJ1360b
(40 western blots)
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