|Reactivity||Human, Mouse, Rat|
|Calculated MW||33199 Da|
|Other Names||Hepatic leukemia factor, HLF|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-term in human HLF was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HLF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Highly expressed in liver; lower levels in lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Hepatic leukemia factor (HLF) is a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors (2). It is a transcription factor related to the CES-2 protein, which controls apoptosis of the NSM serotoninergic neurons (1). HLF has been linked to malignancies of the lymphoid system, but is not normally expressed in these cells. HLF transcripts are detected in the liver, kidney, lung and adult nervous system. It plays a role in the function of differentiated neurons in the adult nervous system (1), and it forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription (2).
1. Hitzler JK, et al. Brain Res. 820(1-2):1-11, 1999 2. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins Pruitt KD, Tatusova, T, Maglott DR Nucleic Acids Res 2007 Jan 1;35(Database issue):D61-5
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