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hnRNP C1/C2 Antibody

Rabbit Monoclonal Antibody

  • WB - hnRNP C1/C2 Antibody AJ1367a
    A.Western blot analysis on (A) HeLa, (B) 293T, (C) MCF-7 and (C) human cerebellum lysates using anti-hnRNP RabMAb (Cat. #AJ1367a), dilution 1:100,000.
  • IHC - hnRNP C1/C2 Antibody AJ1367a
    B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-hnRNP C1/C2 RabMAb (Cat. #AJ1367a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07910
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP3034Y
Calculated MW 33670 Da
Gene ID 3183
Other Names Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1/C2, HNRNPC, HNRPC
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human hnRNP C1/C2 was used as an immunogen.
Dilution WB~~1:50000~100000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionshnRNP C1/C2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HNRPC
Function Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non- coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre- mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'- UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).
Cellular Location Nucleus. Note=Component of ribonucleosomes.
Citations (0)

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Heterogeneous nuclear ribonucleoproteins (hnRNPs) are predominantly nuclear RNA-binding proteins that form complexes with RNA polymerase II transcripts. These proteins function in a variety of cellular activities, ranging from transcription and pre-mRNA processing in the nucleus to cytoplasmic mRNA translation and turnover (1). hnRNP C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation (2). A novel nuclear export is activated by the ROCK signaling pathway to exclude hnRNP C1/C2 from the nucleus, by which the compartmentalization of specific hnRNP components is disturbed in apoptotic cells (3). Overexpression of hnRNP C1/C2 in hepatocellular carcinoma (HCC) tissues has been reported in 70 HCC samples, suggesting its potential as a protein tumor marker (4).


1. Krecic AM, et al. Curr Opin Cell Biol. 11(3):363-71, 1999
2. Hossain M, et al. Molecular and Cellular Biochemistry 296(1-2):151-157, 2007
3. LEE Hsiao-Hui, et al. Journal of Cell Science 117(23):5579-5589, 2004
4. Wei Sun, et al. Molecular & Cellular Proteomics 6:1798-1808, 2007

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Cat# AJ1367a
(40 western blots)
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