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hnRNP K Antibody

Rabbit Monoclonal Antibody

  • WB - hnRNP K Antibody AJ1368a
    A. Western blot analysis on Jurkat cell lysate using anti-hn RNP RabMAb (Cat. #AJ1368a), dilution 1:100,000.
  • IHC - hnRNP K Antibody AJ1368a
    B. Immunohistochemical staining of paraffin-embedded human breast cancer tissue using anti-hnRNP RabMAb (Cat. #AJ1368a).
  • IF - hnRNP K Antibody AJ1368a
    C. Fluorescent immunostaining of HeLa cells using anti-hnRNP RabMAb. (Cat. #AJ1368a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61978
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP943Y
Calculated MW 50976 Da
Gene ID 3190
Other Names Heterogeneous nuclear ribonucleoprotein K, hnRNP K, Transformation up-regulated nuclear protein, TUNP, HNRNPK, HNRPK
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human hnRNP was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated hnRNP K.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionshnRNP K Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HNRPK
Function One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Cellular Location Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53- responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702)
Research Areas
Citations (0)

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The hnRNP-K family of acidic nuclear proteins has been identified using a monoclonal antibody that distinguishes between quiescent and proliferating human keratinocytes. The family, which is composed of four major proteins (hnRNPs-K A, B, C and D) and their modified forms, is present in similar overall levels in quiescent and proliferating normal keratinocytes although clear differences were observed in the levels of some of the individual variants (1). hnRNP-K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals (2). hnRNP-K has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis, for instance hnRNP K increases transcription of the oncogene c-myc and hnRNP K expression is regulated by the p53/MDM 2 pathway (3).


1. Dejgaard K, et al. J Mol Biol. 236(1):33-48, 1994.
2. Mikula M, et al. Proteomics (8):2395-406, 2006.
3. Carpenter B, et al. Br J Cancer 95(7):921-7, 2006.

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Cat# AJ1368a
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