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HPK1 Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - HPK1 Antibody (N-term) AJ1371a
    A. Western blot analysis on Raji cell lysate using anti-HPK1 RabMAb (Cat. #AJ1371a), dilution 1:5,000.
  • IHC - HPK1 Antibody (N-term) AJ1371a
    B. Immunohistochemical analysis of paraffin-embedded human lymph node using anti-HPK1 RabMAb (Cat. #AJ1371a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92918
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP630Y
Calculated MW 91296 Da
Gene ID 11184
Other Names Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1
Target/Specificity A synthetic peptide corresponding to residues in the N-term of human HPK1 was used as immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHPK1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP4K1
Synonyms HPK1
Function Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
Tissue Location Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine
Research Areas
Citations (0)

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The hematopoietic progenitor kinase 1 (HPK1) is a mammalian hematopoiesis-specific Ste20 homologue belonging to the germinal center (GC) kinase family, which contains at least 20 kinases (1). HPK1 is implicated in a variety of signaling systems, including epidermal growth factor, transforming growth factor-beta, erythropoietin, prostaglandin E 2, and T cell receptor and B cell receptor stimulation. HPK1 is also involved in Fas ligation-mediated apoptosis, NF-B activation and a highly specific activator of the JNK/SAP signaling pathway (2-5). Phosphorylation of HPK1 on threonine 165, serine 171 and tyrosine 379 is a prerequisite for its enzymatic activation in response to immunoreceptor stimulation (6).


1. Dan, I., N. M. Watanabe, and A. Kusumi. 2001. Trends Cell Biol. 11:220-230
2. Anafi, M., Kiefer, F., Gish, G. D., Mbamalu, G., Iscove, N. N., and Pawson, T. (1997) J. Biol. Chem. 272, 27804-27811
3. Wang, W., Zhou, G., Hu, M. C.-T., Yao, Z., and Tan, T.-H. (1997) J. Biol. Chem. 272, 22771-22775
4. Liu, S. K., Smith, C. A., Arnold, R., Kiefer, F., and McGlade, C. J. (2000) J. Immunol. 165, 1417-1426
5. Chen, Y.-R., Meyer, C. F., Ahmed, B., Yao, Z., and Tan, T.-H. (1999) Oncogene 18, 7370-7377
6. Tsuji et al. 2001. J. Exp. Med. 194:529-539

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Cat# AJ1371a
(40 western blots)
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