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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSD17B1 Antibody (C-term)   

HSD17B1 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - HSD17B1 Antibody (C-term) AJ1373a
    A. Western blot analysis on human placenta lysate using anti-HSD17B1 RabMAb (Cat. #AJ1373a), dilution 1:100,000.
  • IHC - HSD17B1 Antibody (C-term) AJ1373a
    B. Immunohistochemical staining of paraffin-embedded human placenta using anti-HSD17B1 RabMAb (Cat. #AJ1373a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14061
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1682Y
Calculated MW 34950 Da
Gene ID 3292
Other Names Estradiol 17-beta-dehydrogenase 1, 17-beta-hydroxysteroid dehydrogenase type 1, 17-beta-HSD 1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, E2DH, Placental 17-beta-hydroxysteroid dehydrogenase, HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human HSD17B1 was used as an immunogen.
Dilution WB~~1:100000~200000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSD17B1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSD17B1
Synonyms E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C
Function Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4)


1. Murdock GL, et al. J Biol Chem 258(19):11460-4, 1983.
2. Ghosh D, et al. Structure 3(5):503-13, 1995.
3. Huang YW, et al. Mol Endocrinol 15(11):2010-20, 2001
4. Geissler WM, et al. Nat Genet 7(1):34-9, 1994.

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Cat# AJ1373a
(40 western blots)
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