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HSP60 Antibody

Rabbit Monoclonal Antibody

  • WB - HSP60 Antibody AJ1379b
    A. Western blot analysis on T47D cell lysate using anti-Hsp60 RabMAb (Cat. #AJ1379b), dilution 1:5000
  • IHC - HSP60 Antibody AJ1379b
    B. Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-Hsp60 RabMAb (Cat. #AJ1379b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10809
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1006Y
Calculated MW 61055 Da
Gene ID 3329
Other Names 60 kDa heat shock protein, mitochondrial, 60 kDa chaperonin, Chaperonin 60, CPN60, Heat shock protein 60, HSP-60, Hsp60, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein, HSPD1, HSP60
Target/Specificity A synthetic peptide corresponding to residues in the internal region of human Hsp60 was used as an immunogen.
Dilution WB~~1:5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSP60 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPD1
Synonyms HSP60
Function Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
Cellular Location Mitochondrion matrix.
Research Areas
Citations (0)

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The 60-kDa Heat Shock Protein (Hsp60) is a highly conserved member of the molecular chaperone network commonly imported into the mitochondria to assist in the folding and assembly of mitochondrial proteins (1). Under environmental stress conditions, synthesis of Hsp60 is up-regulated then involved in gene expression regulation, DNA replication, signal transduction, differentiation, apoptosis, cellular senescence or immortalization (2). Hsp60 is also believed to protect mitochondrial ATPase activity under conditions of increasing temperature (3). Hsp60, along with Hsp70, has also been shown to play a role in a danger signalling cascade in response to bacterial infection (4).


1. Prasad YM, et al. Mol Cell Biol (8):3979-86, 1990
2. Czarnecka AM, et al. Cancer Biol Ther. (7):714-20, 2006
3. Patriarca EJ, Exp Cell Res. (1):57-64, 1990
4. Davies EL, et al. Clin Exp Immunol. (1):183-9, 2006

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Cat# AJ1379b
(40 western blots)
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