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HSP70 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - HSP70 Antibody (C-term) AJ1380a
    A. Western blot analysis on HeLa cell lysate using anti-Hsp70 RabMAb (Cat. #AJ1380a).
  • IHC - HSP70 Antibody (C-term) AJ1380a
    B. Immunohistochemical staining of paraffin-embedded human prostate carcinoma using anti-Hsp70 RabMAb (Cat. #AJ1380a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08107
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1007Y
Calculated MW 70052 Da
Gene ID 3303;3304
Other Names Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP701/HSP702, HSPA1A, HSPA1, HSX70
Target/Specificity A synthetic peptide corresponding to residues near the C-term of human Hsp70 was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSP70 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HSPA1, HSX70
Function In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
Cellular Location Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Tissue Location HSPA1B is testis-specific.
Research Areas
Citations ( 0 )


The 70-kDa Heat Shock Protein (Hsp70) is a highly conserved member of the molecular chaperone network commonly found in nuclear, cytosolic, mitochondrial and endoplasmic reticulum compartments of all eukaryotic and prokaryotic cells. Hsp70 uses ATP binding and hydrolysis to assist in efficient folding of both newly created and stress-denatured polypeptides. (1). Under environmental stress conditions, synthesis of Hsp70 is quickly up-regulated and redistributed throughout the cell. (2). It has been shown that Hsp70 has the ability to bind with high affinity to the plasma membrane, activate NF-KappaB and also up-regulate expression of pro-inflammatory cytokines tumor necrosis factor (TNF)-?, interleukin (IL)-1? and IL-6 in human monocytes (3).


1. Yam AY, et al. J Biol Chem 50:41252-61, 2005
2. Prohaszka Z, et al. Cell Stress Chaperones 1:17-22, 2002
3. Asea A. J Biol Chem 17:15028-34, 2002

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Cat# AJ1380a
(40 western blots)
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