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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSP90 beta Antibody   

HSP90 beta Antibody

Rabbit Monoclonal Antibody

  • WB - HSP90 beta Antibody AJ1382a
    A. Western blot analysis on Hela cell lysate using anti-Hsp90 ? (N-term) RabMAb (Cat. #AJ1382a), dilution 1:500.
  • IHC - HSP90 beta Antibody AJ1382a
    B. Immunohistochemical analysis of paraffin-embedded urinary bladder carcinoma using anti-Hsp90 ? (N-term) RabMAb (Cat. #AJ1382a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08238
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names E296
Calculated MW 83264 Da
Gene ID 3326
Other Names Heat shock protein HSP 90-beta, HSP 90, Heat shock 84 kDa, HSP 84, HSP84, HSP90AB1, HSP90B, HSPC2, HSPCB
Target/Specificity A synthetic peptide corresponding to residues in N-terminus of human Hsp90 β was used as immunogen.
Dilution WB~~1:100~500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSP90 beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSP90AB1
Synonyms HSP90B, HSPC2, HSPCB
Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Cellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations (0)

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The 90-kDa heat shock protein (Hsp90) is a highly conserved, and abundant cytosolic homodimeric molecular chaperone (1). Hsp90 is distinguished from other chaperones in that most of its known substrates are signal transduction proteins, non activated steroid hormone receptors, several protooncogenic tyrosine and serine/threonine kinases and actin (2-3). Two isoforms which correspond to the major and minor isoform , (Hsp90 α and Hsp90 β ) can be found in nearly equal amount in humans, and operates as part of a multichaperone machinery in the cytosol, which includes Hsp70, peptidyl-prolyl isomerases and other cochaperones (3).


1. Lees-Miller S., Anderson C.W.; Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.;J. Biol. Chem. 264:2431-2437(1989).
2. Lees-Miller S., Anderson C.W.; The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues.; J. Biol. Chem. 264:17275-17280(1989).
3. Lotz G.P., Lin H., Harst A., Obermann W.M.J.; Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.; J. Biol. Chem. 278:17228-17235(2003).

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Cat# AJ1382a
(40 western blots)
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