|Calculated MW||19348 Da|
|Other Names||Interferon gamma, IFN-gamma, Immune interferon, IFNG|
|Target/Specificity||A synthetic peptide corresponding to residues human IFN-γ was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IFN gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.|
|Tissue Location||Released primarily from activated T lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
Interferons (IFNs) plays a crucial role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. In particular, Interferon gamma (IFN-γ), a sole member of Type II IFN family, is involved in the lymphocyte activation and the regulation of lymphocyte subsets (proliferation, differentiation) (1). IFN-γ is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFN-γ expression is induced by IL-2, TNF-α and IL-12 and suppressed by IL-4, IL-10, and TGF-β (2). IFN-γ binds to IFN-γ receptor (IFNGR) which stimulates various immuno-responses, such as macrophages activation and enhancement of the type I IFNs anti-viral and anti-tumor activities. In immunocompetent host cells, IFN-γ protects against tumor development and directs immunogenic phenotype (3). IFN-γ has been implicated various human diseases, such as multiple sclerosis and insulin-dependent diabetes mellitus (4).
1. Bach EA et al. Annu. Rev. Immunol. 15;563-591, 1997.
2. Sen, GC et al. Viruses and interferons Annu. Rev. Microbiol. 55:255
3. Schroder K et al. Journal of Leukocyte Biology, 75:163-189, 2004.
4. Panitch HS et al. Lancet 1,893-895, 1987.
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