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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IFN-alpha R1 Antibody (C-term)   

IFN-alpha R1 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - IFN-alpha R1 Antibody (C-term) AJ1388a
    A. Western blot analysis on K562 cell lysate using anti-IFN-alpha R1 RabMAb (Cat. #AJ1388a), dilution 1:20,000.
  • FC - IFN-alpha R1 Antibody (C-term) AJ1388a
    B. Flow cytometric analysis of permeabilized K562 cells using anti-IFN-alpha R1 RabMAb (red) (Cat. #AJ1388a) or a rabbit IgG (negative) (green).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17181
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP899Y
Calculated MW 63525 Da
Gene ID 3454
Other Names Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1, IFNAR1, IFNAR
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human IFN-α R1 was used as an immunogen. This antibody is specific for the 90kda precursor and the full-length of IFN-α R1 protein.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIFN-alpha R1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IFNAR
Function Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
Cellular Location Isoform 1: Membrane; Single-pass type I membrane protein
Tissue Location IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R
Research Areas
Citations ( 0 )


Interferon alpha receptor 1 (IFN-? R1) is a class II cytokine receptor that belongs to the type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- ? R1 is a 135-kDa signal transducing subunit of the IFN alpha/beta receptor complex (IFN-? R) (1). IFN-? R1 is phosphorylated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-? R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-? R1 (2).


1. Kotenko SV, et al Nat Acad Sci USA, 96:5007-5012, 1999.
2. Constantinescu SN, et al Proc Natl Acad Sci USA 91:9602-9606, 1994.

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Cat# AJ1388a
(40 western blots)
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