|Calculated MW||18086 Da|
|Other Names||Interleukin-15, IL-15, IL15|
|Target/Specificity||A recombinant human IL-15 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.|
|Cellular Location||Isoform IL15-S48AA: Secreted.|
|Tissue Location||Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin 15 (IL-15) is a cytokine that shares many biological activities with IL-2. Both cytokines interact with the β and γ component of the IL-2 receptor. However, unlike IL-2 which is secreted only by T cells, IL-15 is expressed preferentially by nonlymphoid tissues, epithelial, and fibroblast cell lines (1). Two isoforms of human IL-15 are known. The longer form is localized to the plasma membrane or may be secreted, while the other (the shorter form) is found within the cytoplasm and the nucleus (2). IL-15 regulates T and natural killer cell activation and proliferation, causes B cell proliferation and differentiation and stimulates chemotaxis of T cells (3-4). It also induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. High concentrations of IL-15 have been observed in inflamed joints of rheumatoid arthritis patients, suggesting a role for IL-15 in inflammatory diseases where there is recruitment of leukocytes (5).
1. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D, EMBO J 13:2822, 1994
2. Gaggero, A., B. Azzoarone, C. Andrei, A. Mishal, R. Meazza, E. Zappia, A. Rubertelli, S. Ferrini. 1999. Eur. J. Immunol. 29:1265.
3. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH, J Immunol 154:483, 1995
4. Wilkinson PC, Liew FY: Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181:1255, 1995
5. McInnes, I. B., J. Al-Mughales, M. Field, B. P. Leung, F. P. Huang, R. Dixon, R. D. Sturrock, P. C. Wilkinsin, F. Y. Liew. 1998. Nat. Med. 2:175.
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