|Application ||WB, IHC|
|Calculated MW||17628 Da|
|Other Names||Interleukin-2, IL-2, T-cell growth factor, TCGF, Aldesleukin, IL2|
|Target/Specificity||A synthetic peptide corresponding to residues in human IL-2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells.|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin-2 (IL-2) is an immunoregulatory cytokine that functions as a growth factor and central regulator in the immune system (1, 2). It participates in modulating the immune response by helping control the rate of clonal expansion of lymphocytes (3). IL-2 acts through a quaternary receptor signaling complex containing alpha, beta, and common gamma chain receptors (1). IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial for regulation of the immune response. IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (4).
1. Wang X., et al. Science 310:1159-1163, 2005 2. Stauber D.J., et al. Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793, 2006 3. Bamborough P., et al. Structure 2:839-851, 1994 4. The UniProt Consortium, The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195, 2008
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