|Application ||WB, IHC|
|Calculated MW||97336 Da|
|Other Names||Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD131, CSF2RB, IL3RB, IL5RB|
|Target/Specificity||A synthetic peptide corresponding to residues in the C-terminus of human IL-3R Beta was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-3R beta Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin-3 receptor (IL-3R) is a heterodimer cytokine composed of alpha chain and beta chain. IL-3R beta subunit (CD131, beta C) is a common shared beta chain of the receptor for granulocyte- macrophage colony-stimulating factor (GM-CSF) and IL-5 (1). While the beta chain can not bind to the ligand alone, but it is essential for high affinity ligand binding (2). The cytoplasmic portion of the beta chain contains the major domains necessary for ligand-induced proliferation (3). IL-3R beta is expressed in neutrophil, eosinophil, monocyte, and hematpoietic stem cells. A point mutation leading to defective IL-3R beta expression has been associated to Human pulmonary alveolar proteinosis (PAP), a rare cause of respiratory failure (4).
1. Stomski FC, et al. Mol Cell Bio 16:3035-3046, 1996.
2. Hayashida K, et al. Proc Natl Acad Sci USA 87:9655, 1990
3. Dirksen U, et al. J Clin Invest 100:2211-2217, 1997.
4. Weiss M, et al. Blood 82:3298, 1993
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