|Calculated MW||17492 Da|
|Other Names||Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra, IL4|
|Target/Specificity||A synthetic peptide corresponding to residues in human IL-4 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain of the IL-4 receptor alpha chain (IL4-BP). IL-4 is a left-handed four-helix bundle with a short stretch of beta sheet. The structure bears close resemblance to other cytokines such as granulocyte-macrophage colony stimulating factor (GM-CSF). Regions have been identified which are not only important to maintain structure, but could also play a role in receptor binding (2). IL-4 antagonists Y124D and Y124G are presented and shown to be medically important. The site around Y124 is a particularly important epitope responsible for the ability of IL-4 to cause a signal in the target cells (3).
1. Hage T, et al. Cell 97(2):271-81, 1999
2. Wlodawer, A, et al. FEBS Lett 309(1):59-64, 1992
3. Muller T, et al. J Mol Biol 237(4):423-36, 1994
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