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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IL-6 Antibody   

IL-6 Antibody

Rabbit Monoclonal Antibody

  • WB - IL-6 Antibody AJ1400a
    A. Western blot analysis on using anti-Interleukin-6 RabMAb (Cat. #AJ1400a), dilution 1:10,000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05231
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names E457
Calculated MW 23718 Da
Gene ID 3569
Other Names Interleukin-6, IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2, IL6, IFNB2
Target/Specificity A recombinant human IL-6 protein was used as immunogen.
Dilution WB~~1:10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL6
Synonyms IFNB2
Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Cellular Location Secreted.
Research Areas
Citations (0)

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Interleukin-6 (IL-6) is a multifunctional cytokine with a wide variety of biological functions. IL-6 is implicated in the final differentiation of B-cells into immunoglobulin-secreting cells (1), myeloma and plasmacytoma growth (2), nerve cell differentiation, and activation of hepatocytes and mitogen-stimulated helper T cells (3). Upon activation, IL-6 induces at least three major signaling pathways: JAK/STAT, PI-3 kinase and MAPK (4,5).


1. Hirano, T., et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73
2. Brakenhoff, J.P., et al. Molecular cloning and expression of hybridoma growth factor in Escherichia coli. J Immunol. 139: 4116
3. Wong, G.G., et al. Interleukin 6: identification as a hematopoietic colony-stimulating factor. Behring Inst Mitt. 83: 40
4. Taniguchi, T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268: 251
5. Boulton, T.G., et al. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Bi

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Cat# AJ1400a
(40 western blots)
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