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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Indian Hedgehog Antibody (IHH)   

Indian Hedgehog Antibody (IHH)

Rabbit Monoclonal Antibody

  • WB - Indian Hedgehog Antibody (IHH) AJ1404a
    A. Western blot analysis on fetal brain lysate anti-IHH RabMAb (Cat. #AJ1404a).
  • IHC - Indian Hedgehog Antibody (IHH) AJ1404a
    B. Immunohistochemical staining of paraffin-embedded human fetal colon using anti-IHH RabMAb (Cat. #AJ1404a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14623
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1192Y
Calculated MW 45251 Da
Gene ID 3549
Other Names Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, IHH
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human IHH was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIndian Hedgehog Antibody (IHH) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IHH
Function Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
Cellular Location Indian hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note=The N-terminal peptide remains associated with the cell surface. Cell membrane.
Tissue Location Expressed in embryonic lung, and in adult kidney and liver
Research Areas
Citations (0)

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Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer (1). The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (IHH) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone (2). It has been shown that IHH, synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of bone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development (3).


1. Katoh Y, et al. Cancer Biol Ther 4(10):1050-4, 2005.
2. Lee K, et al. Nat Genet. 38(10):1204-9, 2006.
3. Chung UI, et al. J Clin Invest 107(3):295-304, 2001.

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Cat# AJ1404a
(40 western blots)
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