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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Inhibin Alpha Antibody Chain   

Inhibin Alpha Antibody Chain

Rabbit Monoclonal Antibody

     
  • WB - Inhibin Alpha Antibody Chain AJ1405a
    A. Western blot analysis on (A) Hu-Adrenal gland (B) HeLa (C) Hu-placenta and (D) LNCaP lysates using anti-Inhibin alpha chain RabMAb (Cat. #AJ1405a), dilution 1:2000.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P05111
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPY2782
Calculated MW 39670 Da
Gene ID 3623
Other Names Inhibin alpha chain, INHA
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Inhibin alpha chain was used as an immunogen. 20/23 kDa bands consist of the mature alpha chain. 50/53 kDa bands are the entire proprotein.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsInhibin Alpha Antibody Chain is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name INHA
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Cellular Location Secreted.
Tissue Location Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female
Research Areas
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Background

Inhibin alpha chain is a peptide hormone that inhibits the secretion of follitropin by the pituitary gland. Inhibins and activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition (1). Granulosa-cell tumors produce inhibin and since serum inhibin levels reflect the size of the tumor, measurements of inhibin can be used as a marker for primary as well as recurrent disease (2). In the malignant regions of tissue from men with high grade prostate cancer, the expression of the inhibin alpha-subunit gene is suppressed and was not detectable in poorly differentiated tumor cells. These results demonstrate that in contrast to ovarian granulosa cell tumors, inhibin alpha chain is not expressed in poorly differentiated prostate cancer (3).

References

1. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008)
2. Lappohn RE et al, N Engl J Med 321(12):826-7, 1989
3. Mellor SL, et al. J Clin Endocrinol Metab 83(3):969-75, 1998

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Discontinued
Cat# AJ1405a
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