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IRR alpha Antibody subunit

Rabbit Monoclonal Antibody

     
  • WB - IRR alpha Antibody subunit AJ1415a
    A. Western blot analysis of anti-IRR alpha subunit RabMAb (Cat. #AJ1415a), dilution 1:2,000. A: PC12 B: MCF-7 C: Hela D: SHSY5Y
  • IHC - IRR alpha Antibody subunit AJ1415a
    B. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-IRR alpha subunit RabMAb (Cat. #AJ1415a).
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P14616
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP327Y
Calculated MW 143720 Da
Gene ID 3645
Other Names Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, INSRR, IRR
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human IRR alpha subunit was used as immunogen.
Dilution WB~~1:1000~2000
IHC~~1:50~100
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRR alpha Antibody subunit is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name INSRR
Synonyms IRR
Function Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesnt bind any of IR and IGF-1R known ligands (1-2). In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown (3).

References

1. Bolen, J. B., J. S. Brugge. 1997. Annu. Rev. Immunol. 15:371
2. H
3. Zhang B., Roth R. A. J. Biol. Chem., 267: 18320-18328, 1992.

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Discontinued
Cat# AJ1415a
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