|Application ||WB, IHC|
|Calculated MW||41044 Da|
|Other Names||C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CCR3, CMKBR3|
|Target/Specificity||A synthetic peptide corresponding to residues in C-terminal cytoplasmic domain of human CKR3 was used as immunogen. Predicted to cross-react with macaque, based on sequence homology.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCR3/CKR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||In eosinophils as well as trace amounts in neutrophils and monocytes|
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Provided below are standard protocols that you may find useful for product applications.
CKR3, or C-C chemokine receptor type 3, is a G protein-coupled, seven-transmembrane domain receptor protein. The chemokine eotaxin appears to be a highly specific agonist for CKR3, making CKR3 one of the factors responsible for selective recruitment of eosinophils to sites of inflammation (1). It has been shown that more than one chemokine activates CKR3, including eotaxin, RANTES, and MCP-3 (2). Since CKR3 is prominently expressed in eosinophils, it has been named the human eosinophil eotaxin receptor (2,3).
1. Combadiere, C., et al. Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270: 16491
2. Daugherty, B.L., et al. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J Exp Med. 183: 2349
3. Ponath, P.D., et al. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med. 183: 2437
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