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CCR3/CKR3 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - CCR3/CKR3 Antibody (C-term) AJ1417a
    A. Western blot analysis on (1) K562 and (2) Daudi cell lysates using anti-CCR3/CKR3 (C-term) RabMAb (Cat. #AJ1417a), dilution 1:500.
  • IHC - CCR3/CKR3 Antibody (C-term) AJ1417a
    B. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-CKR3/CCR3 (C-term) RabMAb (Cat. #AJ1417a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51677
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names Y31
Calculated MW 41044 Da
Gene ID 1232
Other Names C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CCR3, CMKBR3
Target/Specificity A synthetic peptide corresponding to residues in C-terminal cytoplasmic domain of human CKR3 was used as immunogen. Predicted to cross-react with macaque, based on sequence homology.
Dilution IHC~~1:100
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCR3/CKR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR3
Synonyms CMKBR3
Function Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location In eosinophils as well as trace amounts in neutrophils and monocytes
Research Areas
Citations (0)

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CKR3, or C-C chemokine receptor type 3, is a G protein-coupled, seven-transmembrane domain receptor protein. The chemokine eotaxin appears to be a highly specific agonist for CKR3, making CKR3 one of the factors responsible for selective recruitment of eosinophils to sites of inflammation (1). It has been shown that more than one chemokine activates CKR3, including eotaxin, RANTES, and MCP-3 (2). Since CKR3 is prominently expressed in eosinophils, it has been named the human eosinophil eotaxin receptor (2,3).


1. Combadiere, C., et al. Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270: 16491
2. Daugherty, B.L., et al. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J Exp Med. 183: 2349
3. Ponath, P.D., et al. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med. 183: 2437

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Cat# AJ1417a
(40 western blots)
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