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IRS-4 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - IRS-4 Antibody (C-term) AJ1419a
    A. Western blot analysis on 293 cell lysate using anti-IRS-4 RabMAb (Cat. #AJ1419a), dilution 1:5000.
  • IHC - IRS-4 Antibody (C-term) AJ1419a
    B. Immunohistochemical staining of paraffin-embedded human kidney using anti-IRS-4 RabMAb (Cat. #AJ1419a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14654
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP907Y
Calculated MW 43541 Da
Gene ID 3767
Other Names ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K(+) channel Kir62, Potassium channel, inwardly rectifying subfamily J member 11, KCNJ11
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human IRS-4 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRS-4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNJ11
Function This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Cellular Location Membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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A new member of the IRS family, IRS-4, is a 160-kDa tyrosine kinase which phosphorylates cellular substrates when it is activated by the binding of insulin (1). IRS-4 was originally discovered in human embryonic kidney 293 cells. Subcellular fractionation revealed that about 50% of IRS-4 was located in cellular membranes, and immunofluorescence indicated that IRS-4 was concentrated at the plasma membrane. Immunoelectron microscopy conclusively established that a large portion of the IRS-4 was located at the cytoplasmic surface of the plasma membrane in both the unstimulated and insulin-treated states. IRS-4 was found to be associated with two src homology 2 (SH2) domain-containing proteins, phosphatidylinositol 3-kinase and Grb2, the adaptor to the guanine nucleotide exchange factor for Ras (2).


1. Lavan BE, J Biol Chem 272(34):21403-7, 1997
2. Fantin VR, et al. 273(17):10726-32, 1998.

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Cat# AJ1419a
(40 western blots)
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