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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Lamin B Receptor Antibody Receptor   

Lamin B Receptor Antibody Receptor

Rabbit Monoclonal Antibody

  • WB - Lamin B Receptor Antibody Receptor AJ1433a
    A. Western blot analysis on Jurkat cell lysate using anti-LBR RabMAb (Cat. #AJ1433a), dilution 1:500.
  • IF - Lamin B Receptor Antibody Receptor AJ1433a
    B. Immunofluorescent staining of HeLa cells using anti-LBR RabMAb (Cat. #AJ1433a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14739
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names E398L
Calculated MW 70703 Da
Gene ID 3930
Other Names Lamin-B receptor, Integral nuclear envelope inner membrane protein, LMN2R, LBR
Target/Specificity A synthetic peptide corresponding to residues of human Lamin B Receptor was used as immunogen.
Dilution WB~~1:5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLamin B Receptor Antibody Receptor is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LBR
Function Anchors the lamina and the heterochromatin to the inner nuclear membrane.
Cellular Location Nucleus inner membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).


1. Gruenbaum, Y., et al. Review: nuclear lamins
2. Ye, Q. and H.J. Worman. Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. J. Biol. Chem. 269: 11306
3. Oberhammer, F.A., et al. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J. Cell Biol. 126: 827
4. Rao, L., et al. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135: 1441

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Cat# AJ1433a
(40 western blots)
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