|Application ||WB, IHC|
|Calculated MW||36689 Da|
|Other Names||L-lactate dehydrogenase A chain, LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59, LDHA|
|Target/Specificity||A synthetic peptide corresponding to residues in human LDH-A (muscle subunit) was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LDH-A Antibody (muscle subunit) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Lactate dehydrogenase (LDH) is a ubiquitous enzyme commonly found in wide variety of organisms, including plants and microbes. LDH is involved in the interconversion of the pyruvate and NADH to lactate and NAD+. It is also called Hydroxybutyrate Dehydrogenase (HBD), due to the fact that it can catalyze the oxidation of hydroxybutyrate (1). Lactate dehydrogenase A (LDH-A, LDH muscle subunit, LDH-M) is involved in the final step of anaerobic glycoysis and catalyzes the conversion of L-lactate and NAD to pryruvate and NADH. While it is predominantly expressed in muscle tissue, it is hormonally regulated in rodents and overexpressed during mammary gland tumorigenesis (2). A mutation that cause deficiency in LDH-A has been implicated in exertional myoglobinuria (3).
1. Kopperschlager G et al. J Chromatogr B Biomed Appl. 684(1-2):25-49, 1996
2. Li X et al. Biochem Biophys Res Commun. 320(3):625-634, 2004
3. Kanno T et al. Clin Chim Acta. 173(1):89-98, 1998
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