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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LDL Receptor(LDLR) Antibody (C-term)   

LDL Receptor(LDLR) Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - LDL Receptor(LDLR) Antibody (C-term) AJ1440a
    A. Western blot analysis on HepG2 cell lysate using anti-LDL receptor RabMAb (Cat. #AJ1440a), dilution 1:5000.
  • IHC - LDL Receptor(LDLR) Antibody (C-term) AJ1440a
    B. Immunohistochemical staining of paraffin-embedded human liver using anti-LDLR RabMAb (Cat. #AJ1440a).
  • IF - LDL Receptor(LDLR) Antibody (C-term) AJ1440a
    C. Immunofluorescent staining of HEPG2 cells using anti-LDLR RabMAb (Cat. #AJ1440a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01130
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1553Y
Calculated MW 95376 Da
Gene ID 3949
Other Names Low-density lipoprotein receptor, LDL receptor, LDLR
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human LDL receptor was used as an immunogen. This antibody detects both isoforms of LDL receptor.
Dilution WB~~1:10000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLDL Receptor(LDLR) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Cellular Location Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9
Research Areas
Citations (0)

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The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).


1. Brown MS, et al. Proc Natl Acad Sci 76(7):3330-7, 1979.
2. Davis CG, et al. J Biol Chem 262(9):4075-82, 1987.
3. Agnello V, et al. Proc Natl Acad Sci 96(22):12766-71, 1999

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Cat# AJ1440a
(40 western blots)
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