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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LFA-1a/ITGAL/CD11a Antibody   

LFA-1a/ITGAL/CD11a Antibody

Rabbit Monoclonal Antibody

  • WB - LFA-1a/ITGAL/CD11a Antibody AJ1442a
    A. Western blot analysis on Jurkat cell lysate using anti-LFA-1a RabMAb (Cat. #AJ1442a).
  • IHC - LFA-1a/ITGAL/CD11a Antibody AJ1442a
    B. Immunohistochemical staining of paraffin-embedded human spleen using anti-LFA-1a RabMAb (Cat. #AJ1442a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20701
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1285Y
Calculated MW 128770 Da
Gene ID 3683
Other Names Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human LFA-1a was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLFA-1a/ITGAL/CD11a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD11A
Function Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Leukocytes.
Research Areas
Citations (0)

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In the immune system, integrins have essential roles in leukocyte trafficking and function. These include immune cell attachment to endothelial and antigen-presenting cells, cytotoxicity, and extravasation into tissues (1). Integrin adhesion receptors transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation and survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial for integrin-mediated signaling. JAB1 (Jun activation domain-binding protein 1), a coactivator of the c-Jun transcription factor, has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer formation and normal cell surface expression of these receptors, leading to life-threatening bacterial infections (3)


1. Kellersch B, et al. Results Prob Cell Differ 43:245-57, 2006
2. Bianchi E, et al. Nature 404(6778):617-21, 2000
3. Nelson C, et al. J. Biol Chem 267(5):3351-7, 1992.

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Cat# AJ1442a
(40 western blots)
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