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LIMS1 Antibody

Rabbit Monoclonal Antibody

  • WB - LIMS1 Antibody AJ1445a
    A. Western blot analysis on (A) Jurkat (B) K562 C) HeLa and (D) 293 cell lysates using anti-LIMS1 RabMAb (Cat. #AJ1445a), dilution 1:5000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48059
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1943Y
Calculated MW 37251 Da
Gene ID 3987
Other Names LIM and senescent cell antigen-like-containing domain protein 1, Particularly interesting new Cys-His protein 1, PINCH-1, Renal carcinoma antigen NY-REN-48, LIMS1, PINCH, PINCH1
Target/Specificity A synthetic peptide corresponding to residues within LIM zinc-binding 3 region of human LIMS1 was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLIMS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIMS1
Synonyms PINCH, PINCH1
Function Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
Cellular Location Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in most tissues except in the brain.
Research Areas
Citations (0)

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LIM and senescent cell antigen-like domains 1 (LIMS1, PINCH1) is an adaptor protein which contains five LIM domains. LIM are two zinc finger motifs with links to regulatory function (1). LIMS1 is thought to be involved in integrin and growth factor signaling. During integrin signaling, LIMS1 interacts with ILK, through its LIM domain. LIMS1 also acts as a bridge linking ILK to NCK2, assisting in growth factor signaling pathways. LIMS1 has been linked to coupling surface receptors to downstream signaling molecules involved in the regulation of cell differentiation, cell proliferation, and cell survival (2).


1. Tu Y, et al, Mol. Biol. Cell 9:3367-3382, 1998.
2. Rearden A, et al. Biochem Biophys Res Commun 201(3):1124-31. 1994.

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Cat# AJ1445a
(40 western blots)
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