|Reactivity||Human, Mouse, Rat|
|Calculated MW||37251 Da|
|Other Names||LIM and senescent cell antigen-like-containing domain protein 1, Particularly interesting new Cys-His protein 1, PINCH-1, Renal carcinoma antigen NY-REN-48, LIMS1, PINCH, PINCH1|
|Target/Specificity||A synthetic peptide corresponding to residues within LIM zinc-binding 3 region of human LIMS1 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LIMS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.|
|Cellular Location||Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in most tissues except in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
LIM and senescent cell antigen-like domains 1 (LIMS1, PINCH1) is an adaptor protein which contains five LIM domains. LIM are two zinc finger motifs with links to regulatory function (1). LIMS1 is thought to be involved in integrin and growth factor signaling. During integrin signaling, LIMS1 interacts with ILK, through its LIM domain. LIMS1 also acts as a bridge linking ILK to NCK2, assisting in growth factor signaling pathways. LIMS1 has been linked to coupling surface receptors to downstream signaling molecules involved in the regulation of cell differentiation, cell proliferation, and cell survival (2).
1. Tu Y, et al, Mol. Biol. Cell 9:3367-3382, 1998.
2. Rearden A, et al. Biochem Biophys Res Commun 201(3):1124-31. 1994.
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