|Reactivity||Human, Mouse, Rat|
|Calculated MW||18358 Da|
|Other Names||Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, T-cell translocation protein 2, LMO2, RBTN2, RBTNL1, RHOM2, TTG2|
|Target/Specificity||A synthetic peptide corresponding to residues in human LMO2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Precautions||LMO2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RBTN2, RBTNL1, RHOM2, TTG2|
|Function||Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.|
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Provided below are standard protocols that you may find useful for product applications.
LMO2 (LIM-only protein 2, RBNT2), a member of the LIM-only class of transcriptional co-regulators that consist of two closely spaced cysteine-rich LIM domains has distinct functions in erythropoiesis and in T-cell leukemogenesis. These diverse functions of LMO2 are presumed to be accomplished through physical interaction with different protein partners that bind the LIM domains of LMO2 (1). It is also required for early stages of hematopoiesis, and the LMO2 master gene encodes a protein that has a central and crucial role in the hematopoietic development (2). LMO2 has been identified as a novel oncogene associated with carcinogenesis and prognosis in several malignant tumors (3)
1. Mao S, et al. Oncogene 3:14(13):1531-9, 1997 2. Yamada Y, et al. Proc Natl Acad Sci 4:97(1):320-4, 2000 3. Nakata K, et al. Neoplasia 11(7):712-9, 2009
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