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LRP6 Antibody Phospho (pS1490)

Rabbit Monoclonal Antibody

  • WB - LRP6 Antibody Phospho (pS1490) AJ1449a
    A. Western blot analysis on HeLa cell lysates using anti-Phospho-LRP6 (pS1490) RabMAb (Cat. #AJ1449a), 1:1000 dilution. Cells were either (A) untreated (B) treated with Calyculin
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75581
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP2360Y
Calculated MW 180429 Da
Gene ID 4040
Other Names Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6
Target/Specificity A phospho specific peptide corresponding to residues surrounding serine 1490 of human LRP6 was used as an immunogen. This antibody detects LRP6 phosphorylated on serine 1490.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRP6 Antibody Phospho (pS1490) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRP6
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity).
Tissue Location Widely coexpressed with LRP5 during embryogenesis and in adult tissues
Research Areas
Citations (0)

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LRP6 (low-density lipoprotein receptor-related protein 6) is a single span transmembrane Wnt receptor that interacts with Axin to promote the Wnt-dependent accumulation of beta-catenin. Cells treated with Wnt quickly induce plasma membrane-associated LRP6 aggregates. The aggregates are phosphorylated, and then promote Axin recruitment and beta-catenin stabilization. LRP6 is internalized with caveolin and components of this endocytic pathway are required not only for Wnt-3a-induced internalization of LRP6 but also for accumulation of beta-catenin. Wnt-3a triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated at Serine 1490 by glycogen synthase kinase-3beta (1-2).


1. Bilic J et al. Science 316(5831):1619-22, 2007
2. Yamamoto H, et al. Cell 11(2):213-23, 2006

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Cat# AJ1449a
(40 western blots)
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