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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LRPAP1 Antibody   

LRPAP1 Antibody

Rabbit Monoclonal Antibody

     
  • WB - LRPAP1 Antibody AJ1450a
    A. Western blot analysis on (A) fetal kidney, (B) mouse kidney, (C) rat kidney and (D) 293T cell lysates using anti-LRPAP1 RabMAb (Cat. #AJ1450a), dilution 1:2000.
  • IHC - LRPAP1 Antibody AJ1450a
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-LRPAP1 RabMAb (Cat. #AJ1450a).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P30533
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3327
Calculated MW 41466 Da
Gene ID 4043
Other Names Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Low density lipoprotein receptor-related protein-associated protein 1, RAP, LRPAP1, A2MRAP
Target/Specificity A synthetic peptide corresponding to residues in human LRPAP1 was used as an immunogen.
Dilution WB~~1:500~2000
IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRPAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRPAP1
Synonyms A2MRAP
Function Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
Cellular Location Rough endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment lumen. Golgi apparatus, cis-Golgi network. Golgi apparatus lumen. Endosome lumen. Cell surface. Note=May be associated with receptors at the cell surface.
Research Areas
Citations (0)

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Background

The low density lipoprotein receptor-related protein-associated protein 1 (LRPAP1/RAP) is an antagonist and molecular chaperone protein that binds tightly to low-density lipoprotein receptor family members and thereby prevents the binding of all known ligands, including alpha 2-macroglobulin and chylomicron remnants. LRPAP1 is present on the cell surface where it is an effective inhibitor of ligand binding to the kidney glycoprotein 330 (gp330), but is most abundant in the endoplasmic reticulum lumen and may function in receptor folding and/or trafficking (1-3).

References

1. Lee D, et al. Mol Cell. 22(3):423-30, 2006
2. Willnow TE, et al. Proc Natl Acad Sci U S A. 92(10):4537-41, 1995
3. Orlando RA, et al. Proc Natl Acad Sci U S A. 91(8):3161-5, 1994

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Discontinued
Cat# AJ1450a
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