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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LRPAP1 Antibody   

LRPAP1 Antibody

Rabbit Monoclonal Antibody

  • WB - LRPAP1 Antibody AJ1450a
    A. Western blot analysis on (A) fetal kidney, (B) mouse kidney, (C) rat kidney and (D) 293T cell lysates using anti-LRPAP1 RabMAb (Cat. #AJ1450a), dilution 1:2000.
  • IHC - LRPAP1 Antibody AJ1450a
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-LRPAP1 RabMAb (Cat. #AJ1450a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30533
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3327
Calculated MW 41466 Da
Gene ID 4043
Other Names Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Low density lipoprotein receptor-related protein-associated protein 1, RAP, LRPAP1, A2MRAP
Target/Specificity A synthetic peptide corresponding to residues in human LRPAP1 was used as an immunogen.
Dilution WB~~1:500~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRPAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms A2MRAP
Function Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
Cellular Location Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum
Research Areas
Citations (0)

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The low density lipoprotein receptor-related protein-associated protein 1 (LRPAP1/RAP) is an antagonist and molecular chaperone protein that binds tightly to low-density lipoprotein receptor family members and thereby prevents the binding of all known ligands, including alpha 2-macroglobulin and chylomicron remnants. LRPAP1 is present on the cell surface where it is an effective inhibitor of ligand binding to the kidney glycoprotein 330 (gp330), but is most abundant in the endoplasmic reticulum lumen and may function in receptor folding and/or trafficking (1-3).


1. Lee D, et al. Mol Cell. 22(3):423-30, 2006
2. Willnow TE, et al. Proc Natl Acad Sci U S A. 92(10):4537-41, 1995
3. Orlando RA, et al. Proc Natl Acad Sci U S A. 91(8):3161-5, 1994

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Cat# AJ1450a
(40 western blots)
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