|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||41466 Da|
|Other Names||Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Low density lipoprotein receptor-related protein-associated protein 1, RAP, LRPAP1, A2MRAP|
|Target/Specificity||A synthetic peptide corresponding to residues in human LRPAP1 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LRPAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.|
|Cellular Location||Rough endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment lumen. Golgi apparatus, cis-Golgi network. Golgi apparatus lumen. Endosome lumen. Cell surface. Note=May be associated with receptors at the cell surface.|
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Provided below are standard protocols that you may find useful for product applications.
The low density lipoprotein receptor-related protein-associated protein 1 (LRPAP1/RAP) is an antagonist and molecular chaperone protein that binds tightly to low-density lipoprotein receptor family members and thereby prevents the binding of all known ligands, including alpha 2-macroglobulin and chylomicron remnants. LRPAP1 is present on the cell surface where it is an effective inhibitor of ligand binding to the kidney glycoprotein 330 (gp330), but is most abundant in the endoplasmic reticulum lumen and may function in receptor folding and/or trafficking (1-3).
1. Lee D, et al. Mol Cell. 22(3):423-30, 2006
2. Willnow TE, et al. Proc Natl Acad Sci U S A. 92(10):4537-41, 1995
3. Orlando RA, et al. Proc Natl Acad Sci U S A. 91(8):3161-5, 1994
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