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MAG Antibody

Rabbit Monoclonal Antibody

  • WB - MAG Antibody AJ1453a
    A. Western blot analysis on rat brain lysate using anti-MAG RabMAb (Cat. #AJ1453a), dilution 1:5000.
  • FC - MAG Antibody AJ1453a
    B. Flow cytometric analysis of PC-12 cells using anti-MAG RabMAb (red) (Cat. #AJ1453a) or a rabbit IgG (negative) (green).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20916
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP971Y
Calculated MW 69069 Da
Gene ID 4099
Other Names Myelin-associated glycoprotein, Siglec-4a, MAG, GMA
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human MAG was used as an immogen.
Dilution WB~~1:500~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAG Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAG
Synonyms GMA
Function Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Myelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination (1). Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG (2). MAG has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron (3). Results also suggest that MAG binds to a specific receptor and initiates a signal transduction cascade to effect inhibition. These results indicate that soluble dMAG detected in vivo could contribute to the lack of regeneration in the mammalian CNS after injury (4).


1. Barton DE, et al. Genomics 1(2):107-12, 1987
2. Liu BP, et al. Science 297(5584):1190-3, 2002
3. Marta CB, et al. Neuron Glia Biol 1(1):35-46, 2004
4. Tang S, et al. Mol Cell Neurosci 9(5-6):333-46, 1997

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Cat# AJ1453a
(40 western blots)
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