|Application ||WB, FC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||69069 Da|
|Other Names||Myelin-associated glycoprotein, Siglec-4a, MAG, GMA|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-terminus of human MAG was used as an immogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAG Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Myelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination (1). Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG (2). MAG has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron (3). Results also suggest that MAG binds to a specific receptor and initiates a signal transduction cascade to effect inhibition. These results indicate that soluble dMAG detected in vivo could contribute to the lack of regeneration in the mammalian CNS after injury (4).
1. Barton DE, et al. Genomics 1(2):107-12, 1987
2. Liu BP, et al. Science 297(5584):1190-3, 2002
3. Marta CB, et al. Neuron Glia Biol 1(1):35-46, 2004
4. Tang S, et al. Mol Cell Neurosci 9(5-6):333-46, 1997
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