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MHC class I Antibody

Rabbit Monoclonal Antibody

     
  • WB - MHC class I Antibody AJ1478b
    A. Western blot analysis on (A) Raji (B) THP-1 cell lysate using anti-MHC class I RabMAb (Cat. #AJ1478b), dilution 1:500.
  • IHC - MHC class I Antibody AJ1478b
    B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-MHC1 RabMAb (Cat. #AJ1478b).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P30443
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR1394Y
Calculated MW 40846 Da
Gene ID 3105
Other Names HLA class I histocompatibility antigen, A-1 alpha chain, MHC class I antigen A*1, HLA-A, HLAA
Target/Specificity A synthetic peptide corresponding to residues in human MHC class 1 was used as an immunogen.
Dilution WB~~1:500~1000
IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMHC class I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HLA-A
Synonyms HLAA
Function Involved in the presentation of foreign antigens to the immune system.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

The antigenic agglomerate major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8-positive T cells. It is now recognized that the products of the MHC genes are antigen-presenting molecules (APM) designed for the presentation of antigen fragments (peptides) to the T-cell receptor, thus participating in the immune response (1). Recently shown is a mechanism of antigen acquisition for cross-presentation that couples the antigen presentation system of two adjacent cells and is lost in most tumours: gap-junction-mediated intercellular peptide coupling for presentation by bystander MHC class I molecules and transfer to professional antigen presenting cells for cross-priming (2). The mammalian vomeronasal organ detects social information about gender, status, and individuality. It has been shown that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gao- and V2R receptor-expressing zone of the vomeronasal epithelium (3).

References

1. Hedrick SM, et al. Cell 70(2):177-80, 1992.
2. Neijssen J, et al. Nature 434(7029):83-8, 2005.
3. Leinders-Sufall T, et al. Science 306(5698):1033-7, 2004.

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Discontinued
Cat# AJ1478b
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