|Calculated MW||10085 Da|
|Other Names||C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, PAT 4641, SIS-beta, Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein, MIP-1-alpha(4-69), LD78-alpha(4-69), CCL3, G0S19-1, MIP1A, SCYA3|
|Target/Specificity||A synthetic peptide corresponding to residues in the C-terminus of human MIP 1 alpha was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MIP-1 alpha Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||G0S19-1, MIP1A, SCYA3|
|Function||Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) belongs to the intercrine beta (chemokine CC) family (1). MIP-1 alpha is involved in the acute inflammatory state, in the recruitment and activation of polymorphonuclear leukocytes and can inhibit infection of cells with human immunodeficiency virus type 1 (HIV-1) (2). MIP-1 alpha also acts as a potent growth, survival, and chemotactic factor in multiple melanoma cells. Two know isoforms of MIP-1 alpha can be found; LD78 alpha and LD78 beta (3). Depending on the isoform or its N-terminal processing, one or more of the CC chemokine receptors CCR1, CCR2, CCR3 and CCR5 can recognize MIP alpha, thus inhibiting HIV infection (4).
1. Jenne, D.; Stanley, K. K. EMBO J. 4: 3153-3157, 1985.
2. S.D. Wolpe, et al., J. Exp. Med. 167 (1988), pp. 570
3. D.R. Forsdycke Biochem. Biophys. Res. Commun. 28 (1985), pp. 619
4. Patricia Menten, Anja Wuyts and Jo Van Damme. Cytokine & Growth Factor Reviews 13,(2002) 455-481
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.