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MKP-3 Antibody

Rabbit Monoclonal Antibody

  • WB - MKP-3 Antibody AJ1487a
    A. Western blot analysis on 3T3 cell lysate using anti-MKP-3 RabMAb (Cat. #AJ1487a), dilution 1:500.
  • IHC - MKP-3 Antibody AJ1487a
    B. Immunohistochemical staining of paraffin-embedded human gastric carcinoma using anti-MKP-3 RabMAb (Cat. #AJ1487a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16828
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR129Y
Calculated MW 42320 Da
Gene ID 1848
Other Names Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, DUSP6, MKP3, PYST1
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human MKP-3 was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMKP-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP6
Synonyms MKP3, PYST1
Function Inactivates MAP kinases. Has a specificity for the ERK family.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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MKP-3 is expressed constitutively in human skin fibroblasts and dephosphorylates and inactivates MAP kinase in vitro and in vivo. MKP-3 displays very low activity towards the stress-activated protein kinases (SAPKs) or RK/p38 in vitro, indicating that these kinases are not physiological substrates for MKP-3. MKP-3 is thought to play a role in the dephosphorylation and inactivation of MAP kinases and are therefore likely to be important in the regulation of diverse cellular processes such as proliferation, differentiation, and apoptosis. For this reason it has been suggested that MAP kinase phosphatases may be tumor suppressors (1). MKP-3 is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis. In situ hybridization studies of MKP-3 in brain reveal enrichment within the CA1, CA3, and CA4 layers of the hippocampus. Observations indicate that MKP-3 is a novel dual-specificity phosphatase that displays a distinct tissue distribution, subcellular localization, and regulated expression, suggesting a unique function in controlling MAP kinase family members (2).


1. Groom LA, et al. EMBO J, 15(14):3621
2. Smith A, et al. Genomics 42(3):524-7, 1997

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Cat# AJ1487a
(40 western blots)
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