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MMP-1 Antibody

Rabbit Monoclonal Antibody

  • WB - MMP-1 Antibody AJ1491a
    A. Western blot analysis on SKBr-3 cell lysate using anti- MMP-1 RabMAb (Cat. #AJ1491a), dilution 1:1000.
  • IHC - MMP-1 Antibody AJ1491a
    B. Immunohistochemical staining of paraffin-embedded human cervical carcinoma using anti-MMP-1 RabMAb (Cat. #AJ1491a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P03956
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1247Y
Calculated MW 54007 Da
Gene ID 4312
Other Names Interstitial collagenase, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG
Target/Specificity A synthetic peptide corresponding to residues on human MMP-1 was used as an immunogen.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP1
Synonyms CLG
Function Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Cellular Location Secreted, extracellular space, extracellular matrix
Research Areas
Citations (0)

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Human interstitial collagenase (matrix metalloproteinase-1, MMP-1), an enzyme whose only known physiologic substrate has heretofore been believed to be the extracellular matrix molecule, collagen. Data indicate that matrix metalloproteinase-1 displays an expanded substrate repertoire that supports the existence of a new interface between connective tissue turnover and serine proteinase inhibitors (1). It has been shown that the MMP-1 functions as a protease agonist of Protease-activated receptors (PAR1) cleaving the receptor at the proper site to generate PAR1-dependent Ca2+ signals and migration. These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion (2). It has also been suggested that increased levels of MMP-1 due to tobacco smoking plays a major role in the aging process of skin since MMP-1 degrades collagen, which accounts for at least 70% of the dry weight of dermis. Significantly more MMP-1 has been detected in the skin of smokers than non-smokers whereas no difference was seen for the tissue inhibitor of metalloproteinases 1 (3).


1. Desrochers PE, et al. J Clin Invest 87(6):2258-65, 1991.
2. Boire A, et al. Cell 120(3):303-13, 2005.
3. Lahmann C, et al. Lancet 357(9260):935-6, 2001.

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Cat# AJ1491a
(40 western blots)
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