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MMP-11 Antibody

Rabbit Monoclonal Antibody

  • WB - MMP-11 Antibody AJ1492a
    A. Western blot analysis on MCF-7 cell lysate using anti-MMP-11 RabMAb (Cat. #AJ1492a), dilution 1:500.
  • IHC - MMP-11 Antibody AJ1492a
    B. Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-MMP-11 RabMAb (Cat. #AJ1492a).
  • IF - MMP-11 Antibody AJ1492a
    C. Immunofluorescent staining of MCF7 cells using anti-MMP11 RabMAb (Cat. #AJ1492a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24347
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1259Y
Calculated MW 54590 Da
Gene ID 4320
Other Names Stromelysin-3, SL-3, ST3, 3424-, Matrix metalloproteinase-11, MMP-11, MMP11, STMY3
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human MMP-11 was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP-11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP11
Synonyms STMY3
Function May play an important role in the progression of epithelial malignancies.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Specifically expressed in stromal cells of breast carcinomas
Research Areas
Citations (0)

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The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium; MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3).


1. Pei D, et al. Nature 375(6528):244-7, 1995.
2. Matrisian LM, et al. Trends Genet 6(4):121-5, 1990.
3. Nakopoulou L, et al. Nephrol Dial Transplant 22(1):109-17, 2007.

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Cat# AJ1492a
(40 western blots)
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