|Application ||WB, IHC, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||54590 Da|
|Other Names||Stromelysin-3, SL-3, ST3, 3424-, Matrix metalloproteinase-11, MMP-11, MMP11, STMY3|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-terminus of human MMP-11 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP-11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play an important role in the progression of epithelial malignancies.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Specifically expressed in stromal cells of breast carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium; MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3).
1. Pei D, et al. Nature 375(6528):244-7, 1995.
2. Matrisian LM, et al. Trends Genet 6(4):121-5, 1990.
3. Nakopoulou L, et al. Nephrol Dial Transplant 22(1):109-17, 2007.
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