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MMP-17 Antibody

Rabbit Monoclonal Antibody

  • WB - MMP-17 Antibody AJ1496a
    A. Western blot analysis on mouse brain lysate using anti-MMP-17 RabMAb (Cat. #AJ1496a), dilution 1:1000.
  • IHC - MMP-17 Antibody AJ1496a
    B. Immunohistochemical staining of paraffin-embedded human lymphoma using anti-MMP-17 RabMAb (Cat. #AJ1496a).
  • IF - MMP-17 Antibody AJ1496a
    C. Immunofluorescent staining of HeLa cells using anti-MMP-17 RabMAb (Cat. #AJ1496a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9ULZ9
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1270Y
Calculated MW 66653 Da
Gene ID 4326
Other Names Matrix metalloproteinase-17, MMP-17, 3424-, Membrane-type matrix metalloproteinase 4, MT-MMP 4, MTMMP4, Membrane-type-4 matrix metalloproteinase, MT4-MMP, MT4MMP, MMP17, MT4MMP
Target/Specificity A synthetic peptide corresponding to residues on human MMP-17 was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP-17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP17
Synonyms MT4MMP
Function Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
Cellular Location Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types
Research Areas
Citations (0)

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Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of the family of Zn(2+)- and Ca(2+)-dependent MMPs. MMP-17 is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A (1). (MMP-17) is expressed mainly in the brain, leukocytes, the colon, the ovary, and the testis. The expression of MMP-17 in leukocytes together with its putative membrane localization suggest that this enzyme could be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators such as tumor necrosis factor-alpha (2). glycosylphospha-tidylinositol (GPI) anchoring of MT4-MMP on the cell surface indicates a unique biological function and character for this proteinase (3).


1. Puente XS, et al. Cancer Res. 56(5):944-9, 1996.
2. Wang Y, et al. J Biol Chem. 274(46):33043-9, 1999.
3. Itoh Y, et al. J Biol Chem 274(48):34260-6, 1999.

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Cat# AJ1496a
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