|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||65043 Da|
|Other Names||Matrix metalloproteinase-21, MMP-21, 3424-, MMP21|
|Target/Specificity||A synthetic peptide that corresponds to residues on human MMP-21 were used as an immunogen. This antibody recognizes 2 isoforms of MMP-21.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP-21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).|
|Tissue Location||Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
Matrix metalloproteinases (MMPs) play key roles in tissue remodelling under normal development and, especially, in diseases ranging from malignancies to stroke. Expression of MMP-21 is controlled uniquely by Pax and Notch transcription factors known to be critical for organogenesis. MMP-21 is expressed transiently in mouse embryogenesis and increased in embryonic neuronal tissues. Observations indicate that there is an important specific function for MMP-21 in embryogenesis, especially in neuronal cells (1). MMP-21 is expressed in various human fetal and adult tissues as well as in cancer cell lines. MMP-21 protein can also be detected in malignancies such as ovarian and colon carcinomas by immunohistochemical staining. Findings suggest that MMP-21 functions in embryogenesis and tumor progression (2). Results suggest that during development, MMP-21 expression is temporally and spatially tightly controlled. Unlike many classical MMPs, it is present in various normal adult tissues. Among epithelial MMPs, MMP-21 has a unique expression pattern in cancer (3).
1. Marchenko GN, et al. Biochem 372(Pt2):503-15, 2003
2. Ahokas K, et al. Gene 301(1-2):31-41, 2002.
3. Ahokas K, et al. Lab Invest 83(12):1887-99, 2003.
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