|Reactivity||Human, Mouse, Rat|
|Calculated MW||29708 Da|
|Other Names||Matrix metalloproteinase-26, MMP-26, 3424-, Endometase, Matrilysin-2, MMP26|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-terminus of human MMP-26 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP-26 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Matrix metalloproteinase 26 (MMP-26) is specifically expressed in cancer cells of epithelial origin, including carcinomas of lung, prostate and breast. Several unique structural and regulatory features, including an unusual 'cysteine-switch' motif, discriminate broad-spectrum MMP-26 from most other MMPs. MMP-26 efficiently cleaves fibrinogen and extracellular matrix proteins, including fibronectin, vitronectin and denatured collagen (1). Expression analysis revealed that matrilysin-2 is detected not only in placenta and uterus but is widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines. These data together with its broad spectrum of proteolytic activity, suggest that MMP-26 may play a role in some of the tissue-remodeling events associated with tumor progression (2). A study of MMP-26 mRNA steady states levels reveals, among the tissue examined, a specific expression in placenta. MMP-26 mRNA could also be detected in several human cell lines such as HEK 293 kidney cells and HFB1 lymphoma cells (3)
1. Marchenko GN, et al. Biochem J 356(3):705-18, 2001
2. Uria JA, et al. Cancer Res 60(17):4745-51, 2000
3. de Coignac AB, et al. Eur J Biochem 267(11):3323-9, 2000
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