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MMP-3 Antibody

Rabbit Monoclonal Antibody

  • WB - MMP-3 Antibody AJ1501a
    A. Western blot analysis on 0.5 ng of recombinant protein using anti-MMP3 RabMAb (Cat. #AJ1501a), dilution 1:1000.
  • IHC - MMP-3 Antibody AJ1501a
    B. Immunohistochemical staining of paraffin-embedded human gastric carcinoma using anti-MMP-3 RabMAb (Cat. #AJ1501a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08254
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1186Y
Calculated MW 53977 Da
Gene ID 4314
Other Names Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1, MMP3, STMY1
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human MMP-3 was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP3
Synonyms STMY1
Function Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Cellular Location Secreted, extracellular space, extracellular matrix
Research Areas
Citations (0)

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Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, and arthritis (1). Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. MMP3 (stromelysin) is a secreted metalloprotease with a wide range of substrate specificities. MMP3 is synthesized in a preproenzyme form with a calculated size of 54 kDa and a 17-amino acid long signal peptide. Data indicate that the expression and the possible involvement of secreted metalloproteases in tumorigenesis result from a specific interaction between the transforming factor and the target cell, which may vary in different species (2). In neural studies, matrix metalloproteinase-3 (MMP-3) was newly induced and activated in stressed dopamine cells, and the active form of MMP-3 (actMMP-3) was released into the medium. The released actMMP-3, as well as catalytically active recombinant MMP-3 (cMMP-3) led to microglial activation and superoxide generation in microglia and enhanced DA cell death. (3).


1. Wilhelm SM, et al. Proc Natl Acad Sci USA 84(19):6725-9, 1987.
2. Pavlovsky AG, et al. Protein Sci, 8(7):1455-62, 1999.
3. Kim YS, et al. FASEB J 21(1):179-87, 2007.

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Cat# AJ1501a
(40 western blots)
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