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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MMP-8 Antibody   

MMP-8 Antibody

Rabbit Monoclonal Antibody

  • WB - MMP-8 Antibody AJ1502a
    A. Western blot analysis on rat lung using anti-MMP8 RabMAb (Cat. #AJ1502a), dilution 1:2000.
  • IHC - MMP-8 Antibody AJ1502a
    B. Immunohistochemical analysis of paraffin-embedded human placenta using anti-MMP8 RabMAb (Cat. #AJ1502a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22894
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1252Y
Calculated MW 53412 Da
Gene ID 4317
Other Names Neutrophil collagenase, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL, MMP8, CLG1
Target/Specificity A synthetic peptide corresponding to residues in human MMP-8 was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP-8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP8
Synonyms CLG1
Function Can degrade fibrillar type I, II, and III collagens.
Cellular Location Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules
Tissue Location Neutrophils.
Research Areas
Citations (0)

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The matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumor invasion and tumour spread (1). Matrix Metalloporteinase 8 (MMP-8, Collagenase-2, Neutrophil Collagenase) functions mainly to degrade fibrillar type I, II, and III collagens, serpins, and aggrecan. MMP-8 degrades by cleaving at one specific on the fibrillar collagens with higher cleave activity on type I compared to type III collagens. MMP-8 is expressed in neutrophils, chondrocytes, and gingival fibroblasts (2).


1. Murray GI, et al. J Pathol, 185(3):256-61
2. Van Lin P, Libert C, Cytokine Growth Factor Rev. 17(4):217-223, 2006.

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Cat# AJ1502a
(40 western blots)
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