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Mo25 Antibody

Rabbit Monoclonal Antibody

  • WB - Mo25 Antibody AJ1504a
    A. Western blot analysis on HeLa cell lysate using anti-Mo25 RabMAb (Cat. #AJ1504a).
  • IHC - Mo25 Antibody AJ1504a
    B. Immunohistochemical staining of paraffin-embedded human brain tissue using anti-Mo25 RabMAb (Cat. #AJ1504a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y376
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1680Y
Calculated MW 39869 Da
Gene ID 51719
Other Names Calcium-binding protein 39, MO25alpha, Protein Mo25, CAB39, MO25
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human Mo25 was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMo25 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAB39
Synonyms MO25
Function Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Cellular Location Cytoplasm.
Research Areas
Citations ( 0 )


Mouse protein 25 alpha (MO25 alpha) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity (1). Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms (2).


1. Milburn CC, et al. Nat Struct Mol Biol 11(2):193-200, 2004
2. Ellingson WJ, et al. Am J Physiol Endocrinol Metab 292(2):400-7, 2006

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Cat# AJ1504a
(40 western blots)

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