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Moesin Antibody

Rabbit Monoclonal Antibody

  • WB - Moesin Antibody AJ1505a
    A. Western blot analysis on HeLa cell lysate using anti-Moesin RabMAb (Cat. #AJ1505a), dilution 1:100,000.
  • IHC - Moesin Antibody AJ1505a
    B. Immunohistochemical staining of paraffin-embedded human tonsils using anti-Moesin RabMAb (Cat. #AJ1505a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P26038
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1863Y
Calculated MW 67820 Da
Gene ID 4478
Other Names Moesin, Membrane-organizing extension spike protein, MSN
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human Moesin was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMoesin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MSN
Function Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment. {ECO:0000250, ECO:0000269|PubMed:18586956}
Tissue Location In all tissues and cultured cells studied.
Research Areas
Citations (0)

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Moesin (membrane-organizing extension spike protein) has previously been characterized as a possible receptor protein for heparan sulfate and also as a cytoskeletal linker protein that stabilizes cell surface microvilli, filopodia and lamellipodia. Data indicate that moesin is identical to the 77-kDa band that copurifies with ezrin in its isolation from human placenta (1). Members of the ezrin-radixin-moesin (ERM) family of membrane-cytoskeletal linking proteins have NH2- and COOH-terminal domains that associate with the plasma membrane and the actin cytoskeleton, respectively (2). It has been demonstrated that ezrin-radixin-moesin proteins are rapidly inactivated after antigen recognition through a Vav1-Rac1 pathway. The resulting disanchoring of the cortical actin cytoskeleton from the plasma membrane decreased cellular rigidity, leading to more efficient T cell-antigen-presenting cell conjugate formation (3).


1. Lankes WT, et al. Proc Natl Acad 88(19):8297-301, 1991
2. Reczek D, et al. J Cell Biol 139(1):169-79, 1997
3. Faure S, et al. Nat Immunol 5(3):272-9, 2004

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Cat# AJ1505a
(40 western blots)
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