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Mst3 Antibody

Rabbit Monoclonal Antibody

  • WB - Mst3 Antibody AJ1514a
    A. Western blot analysis on HeLa cell lysate using anti-Mst 3 RabMAb (Cat. #AJ1514a), dilution 1:5000.
  • IHC - Mst3 Antibody AJ1514a
    B. Immunohistochemical staining of paraffin-embedded human brain using anti-Mst 3 RabMAb (Cat. #AJ1514a).
  • IF - Mst3 Antibody AJ1514a
    C. Immunofluorescent staining of HeLa cells using anti-MST3 RabMAb (Cat. #AJ1514a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6E0
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1468Y
Calculated MW 49308 Da
Gene ID 8428
Other Names Serine/threonine-protein kinase 24, Mammalian STE20-like protein kinase 3, MST-3, STE20-like kinase MST3, Serine/threonine-protein kinase 24 36 kDa subunit, Mammalian STE20-like protein kinase 3 N-terminal, MST3/N, Serine/threonine-protein kinase 24 12 kDa subunit, Mammalian STE20-like protein kinase 3 C-terminal, MST3/C, STK24, MST3, STK3
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human Mst-3 was used as an immunogen.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMst3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK24
Synonyms MST3, STK3
Function Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Cellular Location Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane
Tissue Location Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex
Research Areas
Citations (0)

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The growth of axons is fundamental to the development and repair of brain circuitry. It has been shown that Mst3, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3 is activated in response to trophic factors, and suppressing its expression or its function blocks axon outgrowth (1). Mst3 has been recently demonstrated to undergo a caspase-mediated cleavage during apoptosis. The proteolytic cleavage of the C-terminus of Mst3 caused nuclear translocation of its kinase domain. Mst3 contains both nuclear localization sequence (NLS) and NES signals, which may cooperate to control the subcellular distribution of Mst3 (2). In situ hybridization of rat brain sections indicated that MST3b is widely expressed in different brain regions, with especially high expression in hippocampus and cerebral cortex. When expressed in human embryonic kidney 293 (HEK293) cells, MST3b effectively phosphorylated myelin basic protein, as well as undergoing autophosphorylation (3)


1. Irwin N, et al. Proc. Natl Acad Sci 103(48):18320-5, 2006.
2. Lee WS, et al. REBS Lett 572(1-3):41-5, 2004.
3. Zhou TH, et al. J. Biol Chem 275(4):2513-9, 2000

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Cat# AJ1514a
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