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Musashi-1 Antibody

Rabbit Monoclonal Antibody

  • WB - Musashi-1 Antibody AJ1518a
    A. Western blot analysis on SH-SY-5Y cell lysate using anti-Musashi1 RabMAb (Cat. #AJ1518a), dilution 1:2000
  • IHC - Musashi-1 Antibody AJ1518a
    B. Immunohistochemical staining of paraffin-embedded human brain using anti-Musashi1 RabMAb (Cat. #AJ1518a).
  • IF - Musashi-1 Antibody AJ1518a
    C. Immunofluorescent staining of PC12 cells using anti-Musashi RabMAb (Cat. #AJ1518a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43347
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1302
Calculated MW 39125 Da
Gene ID 4440
Other Names RNA-binding protein Musashi homolog 1, Musashi-1, MSI1
Target/Specificity A synthetic peptide corresponding to residues on the N-terminus of human Musashi1 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMusashi-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MSI1
Function RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Cellular Location Cytoplasm. Nucleus
Tissue Location Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
Research Areas
Citations (0)

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Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Recently, expression of Musashi1 has been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in oncogenic development. Results suggest that Musashi1 expression may be an important factor in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection. (1). Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi1 controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signaling by repressing translation of the Notch inhibitor m-Numb (2).


1. Shu HJ, et al. Biochem Biophys Res Commun 293(1):150- 4, 2002.
2. Okana H, et al. J Cell Sci. 115(7):1355-9, 2002.

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Cat# AJ1518a
(40 western blots)
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