|Application ||WB, IHC, IF|
|Calculated MW||39125 Da|
|Other Names||RNA-binding protein Musashi homolog 1, Musashi-1, MSI1|
|Target/Specificity||A synthetic peptide corresponding to residues on the N-terminus of human Musashi1 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Musashi-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.|
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Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Recently, expression of Musashi1 has been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in oncogenic development. Results suggest that Musashi1 expression may be an important factor in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection. (1). Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi1 controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signaling by repressing translation of the Notch inhibitor m-Numb (2).
1. Shu HJ, et al. Biochem Biophys Res Commun 293(1):150- 4, 2002.
2. Okana H, et al. J Cell Sci. 115(7):1355-9, 2002.
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